DNA molecules on the beautiful backdrop
August 23, 2019

Hotspots meet DNA-encoded libraries

DNA encoded libraries (DEL) have received a lot of attention over the past few years. They’ve been hailed as “highly...

by Geraldine Harriman
Read more
July 31, 2019

Targeting the mTORC1 Pathway With Phenotypic Screening

The conventional approach to drug discovery shines a light on specific target proteins, using an arsenal of biochemical and virtual...

by Jonathan Montagu
Read more
Vector flat style illustration depicting biomedical research concept including handmade textures.
June 30, 2019

Biocentury Innovations shines a new light on allostery

I was excited to participate in Allison Johnson’s recent Biocentury article reflecting on the growing interest of industry in allostery and why...

by Geraldine Harriman
Read more
A scientist working on DNA in a test tube
May 1, 2019

Drugging the Undruggable with Allosteric Small Molecules

Advances in computational, biophysical and library technologies have driven the emergence of a new drug discovery paradigm with the power...

by Nicholas Keen
Read more
Cute tabby cat sniffs on medicine capsules.
April 9, 2019

Cats and the future of machine learning in drug discovery

The predictions around the impact of artificial intelligence (AI) have been broad reaching but it’s clear that not everyone is...

by Jonathan Montagu
Read more
March 11, 2019

HotSpot Frequently Asked Questions

What is a regulatory hotspot? A regulatory hotspot is a privileged allosteric site used by nature to regulate the function...

by Geraldine Harriman
Read more
A button in a suit-like fabric
March 4, 2019

Introducing allokraft

This is an exciting time for small molecule drug discovery and soon for patients, who have been underserved by current...

by Jonathan Montagu
Read more
January 4, 2019

Following Nature’s lead

Lately it seems that allostery is constantly in the news, especially in stories covering a series of high-profile financings by...

by Jonathan Montagu
Read more